Cheng-Shie Wuu

Professor of Clinical Radiation Oncology, Environmental Health Sciences, and Applied Physics

Medical Physics / Radiation Oncology
Office: N. Basement Room 11, Babies/Childrens Hospital
Mail: Radiation Oncology, CUMC
622 West 168th Street
New York, NY 10032

Co-Director of Medical Physics Graduate Program
Division of Environmental Health Sciences, School of Public Health,
and Department of Applied Physics, School of Engineering, Columbia University

Cheng-Shie Wuu’s research focuses on clinical radiation dosimetry. He has been working on the verification of absorbed dose to the target volume for radiation therapy using 3-D gel and radiochromic dosimeter in conjunction with an optical CT scanner, electronic portal imaging device (EPID), as well as Cerenkov radiation. He has developed a fast optical CT scanner for the 3-D diosimeter readout. He has worked on the relative biological effectiveness (RBE) of various types of ionizing radiation in clinical use based on microdosimetric modelling.

Wuu’s main research interest is on the measurement and verification of 3-D dose distribution for complex radiotherapy techniques. He has used gel and radiochromic plastic phantom for radiation measurement. With optical CT scanning of the phantom and 3-D reconstruction software he has successfully demonstrated 3-D dose verification with high resolution and accuracy for advanced radiotherapy techniques. He has developed real-time monitoring of patient transit dosimetry using a commercial EPID. This technique was applied to patient treatment monitoring with an institutional review board (IRB) approved study. He is the Director of Medical Physics, Department of Radiation Oncology, at the Columbia University Medical Center and a Professor of Applied Physics in the School of Engineering and Applied Science at Columbia University. He is also the Co-Director of Medical Physics Graduate Program in the Applied Physics and Applied Mathematics Department. Wuu received a BS in physics from National Tsinghua University in Taiwan and a PhD in biophysics from the University of Kansas in 1985. He is a fellow of the American College of Radiology (ACR 2006), and a fellow of the American Association of Physicists in Medicine (AAPM 2007).

Research Specialty

Microdosimetry, biophysical modeling, dosimetry of brachytherapy, gel dosimetry, second cancers induced by radiotherapy, medical physics


Ph.D. University of Kansas, 1985

Research Experience

  • Associate research scientist, Department of Therapeutic Radiology, Yale University, 1985-1987

Professional Experience

  •        Professor of radiation oncology (in Environmental Health Sciences and in Applied Physics), Columbia University Medical Center, 2002-
  •        Professor of applied physics, 2002-
  •        Director of medical physics, Columbia University Medical Center, 2000-
  •        Co-Director of Medical Physics Graduate Program, 2001-
  •        Associate professor of clinical radiation oncology, Columbia University, 1994-2002
  •        Assistant professor of clinical radiation oncology, Columbia University, 1988-1994

Professional Affiliations

       •         American Association of Physicists in Medicine (AAPM)
American College of Radiology (ACR)
American Society of Radiation Oncology (ASTRO)
Radiation Research Society(RRS)

Honors & Awards

  • Fellow, American College of Radiology, 2006
  • Fellow, American Association of Physicists in Medicine, 2007

Selected Publications

Wuu, CS, Zaider, M, Lee, E, Ennis, RD and Schiff, PB. Dosimetric and Volumetric Criteria for Selecting A Source Activity and/or A Source Type (I-125 or Pd-103) in the Presence of Irregular Seed Placement in Permanent Prostate Implants. Int. J. Radiat. Oncol. Biol. Phys. 47:815-820, 2000.

Wuu, CS, Schiff, PB, Maryanski, M., Borzilllary, S. Liu, T, Weinberger, J. Dosimetry Study of Re-188 Liquid Balloon for Intravasular Brachytherapy Using Polymer Gel Dosimeters and Laser-Beam Optical CT Scanner. Med. Phys., 30(2):132 137, 2003.

Xu, Y., Wuu, C.S., and Maryanski, M. Performance of Optical CT Scanning of Polymer Gels as a Tool for 3D Dose Verification, Med. Phys. 2004;31,3024-3033.

Hall. E. and Wuu, CS Radiation-Induced Second Cancers: The Impact of 3D-CRT and IMRT, Int. J. Radiati. Oncol. Biol. Phys, 56 (1):83-88, 2003.

Wuu, C.S., Xu, Y., and Maryanski, M. 3-D Dose Verification for IMRT Using optical CT Based Polymer Gel dosimetry, Med. Phys. 2006;33(5), 1412-1419. PMID: 16752577.

Berry S.L., Sheu R, Polvorosa C.S., Wuu C.S. Implementation of EPID Transit Dosimetry Based on a Through-Air Dosimetry Algorithm, Med. Phys. 2012;39(1):87-98 PMID: 22225278.

Xu, Y. and Wuu, CS. Evaluation of a rotating mirror-based fast optical CT scanner for gel dosimetry. Phys. Med. Biol. 2013;58:479.

Berry, S.L., Polvorosa, C., Cheng, S., Deutsch, I., Chao, K.S, Wuu, C.S. Initial Clinical Experience Performing patient Treatment Verification with an Electronic Portal Imaging Device” Int J Radiat Oncol Biol Phys, 2014;88(1):204-9.

Qian, X, Admovics, J, Wuu, C.S. Performance of An Improved First-Generation Optical CT Scanner for 3D Dosimetry”, Phys. Med. Biol. 2014;58:321-33. PMID: 24262134.

Wuu, CS, Sheu, R, and Chen, J, Microdosimetric Characteristics of 50 kV x-rays at different depths for breast intraoperative radiotherapy, Radiation Protection Dosimetry , doi:10.1093/rpd/ncv166, 2015.

In the News

·       Wuu Named ACR Fellow (Jan. 10, 2006)


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